
Last year in the UK over 60,000 cancer patients enrolled on clinical trials aimed at improving cancer treatments and making them available to all.
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This trial is looking at a new drug called fostamatinib to treat diffuse large B cell lymphoma (DLBCL) that has continued to grow during treatment (refractory) or come back after treatment (relapsed).
Fostamatinib is a type of biological therapy. It is a cancer growth blocker. We know from research that it may block one of the signals that lymphoma cells need to grow and divide.
The aims of this trial are to find out
You may be able to enter this trial if you
You cannot enter this trial if you
This is an international phase 2 trial. It will recruit at least 60 people from different countries. This is a randomised trial. The people taking part are put into treatment groups by a computer. Neither you nor your doctor will be able to decide which group you are in. And neither of you will know which group you are in either. This is called a double blind trial.
Everyone will have fostamatinib. Half the people will have one dose. The other half will have double the dose.
Fostamatinib is a tablet. You take it twice daily. You can take it with or without food. You can continue taking fostamatinib as long as it is helping you and the side effects aren’t too bad.
As a part of this trial, the researchers will take a blood sample to look at the genetic makeup of a certain protein in your body. This is to find out how your body deals with fostamatinib.
If you agree to take part in this study, the researchers will ask for a sample of tissue before you start treatment and another if your lymphoma starts to get worse while having treatment. They will also ask for a blood sample. If you don’t want to give the tissue samples, blood sample or both for this study, you don’t have to. You can still take part in the trial.
The researchers will ask your permission to access tissue from your tumour that has been stored from previous surgery or biopsy. You must agree to this. If you don’t you can’t take part in this trial.
You see the doctor to have some tests before taking part in this trial. These tests include
You see the doctor regularly during treatment and again a month after you stop taking fostamatinib. At these appointments, you have the same tests as above, apart from the bone marrow test.
The most common side effects of fostamatinib are
Your doctor will talk to you about the possible side effects before you agree to take part in this trial.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr. Kirit Ardeshna
AstraZeneca
Experimental Cancer Medicine Centre (ECMC)
Freephone 0808 800 4040
Last year in the UK over 60,000 cancer patients enrolled on clinical trials aimed at improving cancer treatments and making them available to all.