A trial looking at a different way of giving posaconazole to prevent fungal infection after treatment for some blood cancers

Cancer type:

Acute leukaemia

Acute myeloid leukaemia (AML)

Blood cancers

Chronic leukaemia

Chronic myeloid leukaemia (CML)

Leukaemia

Myelodysplastic syndrome (MDS)

Status:

Results

Phase:

Phase 1

This trial looked at giving posaconazole in a different way to prevent fungal infection after treatment for acute myeloid leukaemia (AML), myelodysplastic syndrome (MDS) and chronic myeloid leukaemia (CML).

More about this trial

Doctors can treat AML, MDS and CML with chemotherapy or a bone marrow or stem cell transplant. One of the side effects of both these treatments is a drop in white blood cells causing an increased risk of infection, including fungal infection.

Posaconazole is a drug that doctors use to treat or prevent fungal infection. It is a liquid that you swallow. The researchers developed another form of posaconazole that you have as a drip into a vein Open a glossary item . The researchers wanted to measure the level of posaconazole in the blood after having it through a drip. They did this by taking blood samples.

The aims of this trial were to find out the

Levels of posaconazole in the blood before and after having it through a drip
Side effects of having posaconazole through a drip
Levels of posaconazole in the blood after switching from having it as a drip to a liquid that is swallowed