
"I am glad that taking part in a trial might help others on their own cancer journey.”
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This trial is looking at having chemotherapy after surgery to remove womb (endometrial) cancer.
Doctors treat womb (endometrial) cancer with surgery. If the cancer hasn’t spread, you will see your specialist in the clinic at the hospital for 5 years. But unfortunately sometimes the cancer can come back.
We know from research that having chemotherapy after surgery to remove cancer can stop, or delay it, from coming back. The researchers want to find out if giving chemotherapy after surgery can help women whose womb cancer hasn’t spread.
To do this half the women in this trial will have carboplatin and paclitaxel chemotherapy after surgery. And the other half won’t.
The aims of this trial are to compare these 2 groups and find out
You may be able to join this trial if you are in one of the following situations. You have womb cancer that is
You must also
You cannot join this trial if any of these apply. You
This is an international phase 3 trial. The researchers need 678 women to join.
It is a randomised trial. The people taking part are put into treatment groups by a computer. Neither you nor your doctor will be able to decide which group you are in. And neither of you will know which group you are in.
You start chemotherapy within 3 months after your surgery. You have the chemotherapy as an injection into a vein every 3 weeks. You have a total of 6 treatments.
The trial team will ask you to fill out a questionnaire at the start of the trial, every 3 months for 2 years and then every 6 months for another 3 years. Women who had chemotherapy will fill in an extra questionnaire after their 4th treatment and when they finish treatment. The questionnaire will ask about side effects and how you’ve been feeling. This is called a quality of life study.
If you agree to take part in this study, the researchers will ask for a sample of your cancer that was removed when you had surgery. If you don’t want to give this sample for research, you don’t have to. You can still take part in the trial.
You see the doctor to have some tests before taking part in this trial. These tests include
During chemotherapy you see the doctor every 3 weeks for blood tests and to see how you are.
Everyone sees the doctor every 3 months for 2 years and then every 6 months for another 3 years.
The most common side effects of carboplatin and paclitaxel are
We have information on carboplatin and paclitaxel
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor Nick Reed
Danish Gynaecologic Cancer Group (DGCG)
European Network of Gynaecological Oncology Trials groups (ENGOT)
European Organisation for Research and Treatment of Cancer (EORTC)
Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
Freephone 0808 800 4040
"I am glad that taking part in a trial might help others on their own cancer journey.”