Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.
A trial looking at central lines for long term chemotherapy (CAVA)
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This trial is comparing different types of central lines that doctors use to give long term chemotherapy.
More about this trial
You can have chemotherapy as an injection into a vein. This is fine for short term treatment. But when you have long term chemotherapy your doctor may suggest having a tube put in that can stay in for a long time. It means that you won’t need to have a needle put into your arm each time you have treatment.
These are generally called
Both the central line and portacath go into your body through a large vein in the centre of your chest. The PICC line goes into a vein in your arm.
Most hospitals use all 3 types of central lines. But they don’t know which is the best or cheapest to use. The researchers want to find this out by comparing them.
Taking part in this trial will not affect any treatment you have.
Who can enter
You may be able to join this trial if all of the following apply.
- You have any type of cancer
- You will be having an anti cancer drug for 3 months or more
- Your doctor is not sure if a tunnelled central line, PICC line or portacath is the best to use
- You are able to have either a tunnelled central line, PICC line or portacath put in
- You are at least 18 years old
You cannot join this trial if any of these apply.
- You have had a tunnelled central line, PICC line or portacath that was removed within the past 2 weeks due to a complication, for example an infection
- Your doctor wants to use your central line to collect stems cells
- If your doctor isn’t able to put the central line into a large vein in your upper arm or chest
- If you have an infection
- You have already taken part in this trial
The researchers need 2,000 people to join this trial.
There are 4 groups in this trial. Your doctor will talk to you about this. When you know which group you are in, a computer will decide which type of central line you will have. This is called randomisation.
People in group 2 will have either a tunnelled central line or portacath.
People in group 3 will have either a PICC line or portacath.
People in group 4 will have either a tunnelled central line or PICC line or portacath.
You have your treatment as your doctor has planned.
The trial team will look at your medical notes to find out information about your cancer, treatment and the central line that you have in place.
The trial team will ask you to fill out 2 questionnaires before you have your central line put in and then the same questionnaires plus an additional one every month until you have it removed. The questionnaires will ask about side effects, how you’ve been feeling and what you think about the central line. This is called a quality of life study.
At the end of the study the researchers may ask you to take part in a group to talk about your experience and views of having the central line in. You don’t have to be part of the group if you don’t want to.
There are no extra hospital visits, unless you choose to take part in the group. This will take place at the hospital.
How to join a clinical trial
Professor Jon Moss
Experimental Cancer Medicine Centre (ECMC)
NHS Greater Glasgow and Clyde
NIHR Health Technology Assessment (HTA) programme