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A trial looking at volrustomig for head and neck cancer that has spread into the surrounding tissue (eVOLVE-HNSCC)

Overview

Cancer types:

Head and neck cancers, Laryngeal cancer, Mouth and oropharyngeal cancer, Pharyngeal cancer

Status:

Open

Phase:

Phase 3

Details

This trial is looking at volrustomig (MEDI5752) for head and neck cancer that has spread into the surrounding tissue and cannot be removed by surgery.

Cancer that has spread into the surrounding tissue is called locally advanced cancer.

It is open to people who have had chemotherapy alongside radiotherapy () as treatment for the following:

  • oropharyngeal cancer

  • mouth (oral) cancer

  • hypopharyngeal cancer

  • laryngeal cancer

  • tongue cancer

  • tonsil cancer

You pronounce volrustomig as vole-rust-oh-mig.

Recruitment start: 10 May 2024

Recruitment end: 20 June 2030

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Professor Kevin Harrington

Supported by

AstraZeneca

Last reviewed: 07 May 2025

CRUK internal database number: 19959

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