A trial looking at volrustomig and chemotherapy for mesothelioma of the lungs (eVOLVE-Meso)

The following bullet points are a summary of the entry conditions for this trial. Talk to your doctor or the trial team if you are unsure about any of these. They will be able to advise you. 

Who can take part

You may be able to join this trial if all of the following apply. You:

• have mesothelioma of the lung (pleural mesothelioma) that has been confirmed with a tissue sample (biopsy )
• have mesothelioma that has spread to another part of the body and you can’t have surgery to remove it with the aim to cure  
• have pleural mesothelioma that your doctor can measure on a scan. The areas of mesothelioma must measure at least 7mm across. Or you have areas of mesothelioma that have spread elsewhere in the body that your doctor can measure on a scan. 
• have a sample of tissue (biopsy) the trial team can access that you had done within 6 months of seeing if you are suitable for the trial. Please note, you may still be able to join the trial if there isn't a tissue sample available. 
• have satisfactory blood test results
• are fully active but might not be able to do heavy physical work (performance status of 0 or 1).  And this hasn’t got worse at the time of being assessed for the trial.
• are willing to use reliable contraception during the trial and for a period after if there is any chance you or your partner could become pregnant 
• weigh at least 35kg (77lb)
• are willing not to donate sperm or eggs during the trial and for a period after 
• are at least 18 years old 

 Who can’t take part

Cancer related
You cannot join this trial if any of these apply. You:

• have mesothelioma that didn’t start in the lining of the lungs 
• have had treatment for mesothelioma of the lungs in the past that included chemotherapy, surgery or radiotherapy. You can take part if you had radiotherapy to treat mesothelioma symptoms if this was more than 2 weeks ago. 
• have had immunotherapy or similar drugs in the past. You can take part if you have had a cancer vaccine.
• have had radiotherapy for another cancer to a wide area or to more than 30% of the bone marrow  within 4 weeks of starting trial treatment. Your doctor will be able to assess this. You can take part if you have had radiotherapy to help with symptoms. 
• have mesothelioma but your doctor can’t work out the cell type  
• have had major surgery within 4 weeks of starting trial treatment or you aren’t better after surgery. You can take part if you had surgery to help with symptoms. 
• have had chemotherapy, radiotherapy, an experimental treatment, a targeted cancer drug  or hormone treatment for another cancer.  
• have cancer that has spread to the brain, spinal cord or tissues that surround the brain or is pressing on the spinal cord (spinal cord compression ). You might be able to take part if you have had treatment, the cancer is stable and you haven’t had steroids  within 14 days of starting trial treatment
• have had another cancer that has got worse or needed treatment in the past 2 years unless it has a low chance of coming back. You can join if it was successfully treated non melanoma skin cancer , lentigo maligna,  carcinoma in situ (CIS ), early bladder cancer or prostate cancer that doesn’t need treatment.
• are taking an experimental drug or using a device as part of another clinical trial. Or you are in the follow up period for a trial that involved a treatment.

Medical conditions
You cannot join this trial if any of these apply. You:

• have or had an autoimmune condition  that needed treatment apart from certain ones. Your doctor will know about this. 
• have had a heart attack in the last 12 months, a significant heart problem  that needs treatment or a problem with your heartbeat. The trial team check if you have a heart condition before you join the trial. 
• have high blood pressure that isn’t controlled with medication
• have scarring of the lungs (interstitial lung disease)
• have a serious problem with your gut (digestive system )
• have an active bleeding problem
• have had a stem cell transplant  or an organ transplant
• have a problem with how your immune system  works 
• have had treatment that damps down the immune system. This includes steroids within 2 weeks of starting trial treatment unless it was a low dose 
• have HIV, an active hepatitis B or hepatitis C infection that isn’t well controlled with medication, an active hepatitis A infection, tuberculosis  or any other severe infection that needs treatment 
• have any other severe or uncontrolled medical condition that could affect you taking part 

Other 
You cannot join this trial if any of these apply. You:

• have already joined this trial even if you didn’t have treatment 
• have had a severe allergic reaction to a targeted cancer drug or cancer vaccine in the past
• are allergic to volrustomig or anything it contains 
• can’t have pemetrexed, carboplatin or cisplatin chemotherapy for any reason 
• have had a live vaccination  within 30 days of starting trial treatment. You can take part if you have had an approved COVID-19 vaccine as these aren’t live.
• are pregnant or breastfeeding