“I think it’s essential that people keep signing up to these type of trials to push research forward.”
A trial looking at a new vaccine treatment for bowel cancer
This trial was looking at a new vaccine called 105 AD7 before surgery for bowel (colorectal) cancer.
105 AD7 is a type of biological therapy called a vaccine. Doctors hope it will stimulate the immune system to recognise and kill bowel cancer cells. They hope that if they give people the vaccine before they have surgery, it will help stop the cancer coming back.
There were 3 groups in this trial. People either had
- 105 AD7 vaccine and a powder called alum to help absorb it
- 105 AD7 with another vaccine called BCG for the first dose, and then with alum after that
- No 105 AD7
The aim of this trial was to find out if 105 AD7 injections could stimulate the immune system. And to find out more about the side effects.
Summary of results
The research team found that 105 AD7 did stimulate the immune system in some patients.
This trial recruited 67 patients who were due to have surgery for bowel cancer. They looked at the number of different cells in the immune system after treatment with 105 AD7.
They found that there was an immune system response in between 4 and 7 out of every 10 patients receiving the vaccine (43% to 69%). The result varied depending on which immune cells the researchers measured and which method they used.
The researchers reported that one of the most important findings was that 105 AD7 stimulated the immune system to produce more ‘tumour necrosis factor alpha’ (TNFa) in 9 out of 13 patients tested (nearly 70%). TNF is a substance that occurs naturally but only in small amounts. It attacks cancer cells. Doctors hope that increasing TNF will be helpful in treating bowel cancer.
We have based this summary on information from the team who ran the trial. The information they sent us has been reviewed by independent specialists (
How to join a clinical trial
Professor JH Scholefield
Cancer Research UK
Nottingham University Hospital NHS Trust