A trial looking at the benefit of radiotherapy after surgery for breast cancer (BIG 2-04 SUPREMO)

Overview

Cancer types:

Breast cancer

Status:

Results

Phase:

Phase 3

Details

This trial looked at whether radiotherapy after surgery helped to stop breast cancer coming back. This was in women who had an intermediate risk of the cancer returning.

Women could join this international trial between 2006 and 2013. The team published a number of results including the latest results in 2025.

Recruitment start: 7 June 2006

Recruitment end: 30 April 2013

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Prof Ian Kunkler

Supported by

Medical Research Council (MRC)

NIHR Clinical Research Network: Cancer

Breast International Group (BIG)

European Organisation for Research and Treatment of Cancer (EORTC)

Experimental Cancer Medicine Centre (ECMC)

Trans Tasman Radiation Oncology Group

Cancer Australia

Trustees of Breast Cancer Institute, Edinburgh and of Edinburgh Cancer Centre

NHS Endowment Funds

Trustees of the Hong Kong and Shanghai Bank

Last reviewed: 17 Jul 2026

CRUK internal database number: 719

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