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A trial looking at selumetinib for people with thyroid cancer when radioactive iodine treatment has stopped working (SEL-I-METRY)

Overview

Cancer types:

Secondary cancers, Thyroid cancer

Status:

Results

Phase:

Phase 3

Details

This trial looked at whether a drug called selumetinib could help thyroid cancer cells absorb more radioactive iodine. And whether this helps control the cancer for longer.

The trial was for people with certain types of thyroid cancer that had grown outside the thyroid or spread to another part of the body.

It was supported by Cancer Research UK. People could join between 2017 and 2019. The team published the results in 2023.

Recruitment start: 28 March 2017

Recruitment end: 15 August 2019

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Professor Jon Wadsley

Supported by

Cancer Research UK

NIHR Clinical Research Network: Cancer

Sheffield Teaching Hospitals NHS Foundation Trust

University of Leeds

Butterfly Thyroid Cancer Trust

AstraZeneca

Sanofi-Genzyme

Other information

This is Cancer Research UK trial number CRUK/14/041.

Last reviewed: 27 Mar 2026

CRUK internal database number: 12867

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