A trial looking at preventing bowel cancer with aspirin or resistant starch in people with Lynch syndrome (CAPP2)

Overview

Cancer types:

Bowel (colorectal) cancer, Colon cancer

Status:

Results

Phase:

Other

Details

This trial was done to see if aspirin or resistant starch could help prevent bowel (colorectal) cancer developing in people with .

The trial was supported by Cancer Research UK. People could join between 1999 and 2005. The team have published several results papers between 2008 and 2022.

Recruitment start: 1 January 1999

Recruitment end: 10 March 2005

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Professor Sir John Burn

Supported by

Stand Up To Cancer

Cancer Research UK

The European Union Biomed research programme

Medical Research Council (MRC)

National Institute for Health Research (NIHR)

Bayer Pharma AG

Barbour Foundation

Other information

Bayer Pharma first started to make aspirin in the 1890s, and people still use it all over the world. It is made from a natural product found in green plants which helps to protect the plants from infection.

Bayer Pharma provided the aspirin tablets and the placebo tablets for the CAPP2 trial. But they didn’t have any say in the research.

Last reviewed: 04 Sept 2026

CRUK internal database number: 15

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