A trial looking at MK-2870 for cancer of the womb (MK-2870-005)

The following bullet points are a summary of the entry conditions for this trial. Talk to your doctor or the trial team if you are unsure about any of these. They will be able to advise you. 

Who can take part

You may be able to join this trial if all of the following apply. You:

• have womb cancer or carcinosarcoma of the womb 
• have cancer that your doctor can see on a scan 
• have a sample of tissue (biopsy ) from a previous sample that the team can use to do some tests on. Or you are willing to have a new sample taken if a previous sample isn’t available. 
• have had chemotherapy that included a platinum drug  or you have had an immunotherapy . Or you have had these treatments together.
• are fit and active but might not be able to do heavy physical work (performance status 0 or 1)
• have satisfactory blood test results 
• are willing to use reliable contraception during the trial and for a period after if there is any chance you could become pregnant
• are at least 18 years old 

Who can’t take part

Cancer related
You cannot join this trial if any of these apply. You:

• have cancer that has spread to the brain or spinal cord or the thin tissue layers that cover them. You can take part if you have had treatment, the cancer is stable and you have stopped taking steroids.
• have neuroendocrine cancer of the womb or sarcoma of the womb. Your doctor will know this. 
• are suitable to have surgery or radiotherapy with the aim to cure 
• have womb cancer or carcinosarcoma of the womb that came back more than 6 months after finishing treatment with the aim to cure. And this treatment included a platinum drug . You can’t take part if you needed more treatment that included a platinum drug for cancer that had come back or spread. 
• have had more than 3 courses of treatment for womb cancer. Your doctor checks which treatment you have had. 
• have had treatment with a drug that works in the same way as MK-2870
• have had another cancer treatment within 4 weeks of being put into a treatment group or it hasn’t cleared from your body yet 
• have had radiotherapy within 2 weeks of starting trial treatment or you have side effects from radiotherapy that meant you needed to take steroids 
• have moderate to severe side effects from past cancer treatments. This doesn’t apply if you have hair loss or white patches on your skin. 
• have another cancer that is getting worse or needed treatment in the last 3 years. You can take part if you had successfully treated basal cell skin cancer , squamous cell skin cancer  or early cancer of the bladder. 

Medical conditions
You cannot join this trial if any of these apply. You:

• have moderate to severe numbness and tingling in your hands or feet (peripheral neuropathy )
• have severe dry eyes, inflammation of the eyelids or a problem with the clear covering in your eye (cornea)
• have inflammatory bowel disease and you are taking medication to damp down the immune system  or you have had inflammatory bowel disease in the past 
• have had a heart attack in the last 6 months or a significant heart problem  that needs treatment. The trial team check if you have a heart condition before you join the trial. 
• have had a stroke  in the last 6 months 
• take medication that affects substances in the body called CYP enzymes within 2 weeks of starting trial treatment. Your doctor can tell you more about this.
• have HIV unless you are having treatment and it is under control. You can’t take part if you have had Kaposi’s sarcoma or a disease called multicentric Castleman’s disease. Your doctor will know this. 
• have active hepatitis B or hepatitis C unless you have had or are having treatment and it is under control. You can’t take part if you have both hepatitis B and hepatitis C. 
• have another active infection that needs treatment to the whole body
• are taking an experimental drug or using a device as part of another clinical trial. This is if it is within 4 weeks of being put in a treatment group for this trial.
• have had major surgery and you aren’t better yet 
• have any other medical condition or mental health problem that could affect you taking part 

Other
You cannot join this trial if any of these apply. You:

• have had a live vaccine  within 30 days of the start of treatment. Please note that the approved COVID-19 vaccines are allowed as they aren’t live. 
• have a problem with drugs or alcohol 
• are allergic to MK-2870, similar drugs, any of the other treatments in the trial or anything they contain 
• are pregnant or breastfeeding