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Phase 2
This trial is looking at whether a drug called metformin might reduce the risk of cancer developing in people with Li Fraumeni Syndrome.
(LFS) is an condition. People who have LFS have an increased risk of developing different types of cancer.
Recruitment start: 20 December 2023
Recruitment end: 31 March 2026
Please note: In order to you will need to discuss it with your doctor, unless otherwise specified.
Professor Sarah Blagden
Cancer Research UK
The George Pantziarka TP53 Trust
Medical Research Council (MRC)
National Institute for Health & Care Research (NIHR)
Oxford Clinical Trials Research Unit (OCTRU)
Oncology Clinical Trials Office (OCTO)
University of Oxford
Last reviewed: 26 Feb 2026
CRUK internal database number: 19461
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