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A trial looking at immunotherapy for people with some types of blood cancer using CAR T-cells (ALLCAR19)

Overview

Cancer types:

Acute leukaemia, Acute lymphoblastic leukaemia (ALL), Blood cancers, Cell type, Chronic leukaemia, Chronic lymphocytic leukaemia (CLL), High grade lymphoma, Hodgkin lymphoma, Leukaemia, Low grade lymphoma, Lymphoma, Non-Hodgkin lymphoma (NHL)

Status:

Closed

Phase:

Phase 1

Details

This trial is looking at changing immune cells to recognize and attack cancer cells. The changed immune cells are called CD19CAR T-cells.

It is for people who have either:

  • acute lymphoblastic leukaemia with a high risk of it coming back after treatment (high risk ALL) or ALL that has come back after treatment (relapsed)

  • certain types of slow growing (low grade) non-Hodgkin lymphoma

  • diffuse large B cell lymphoma (DLBCL)

  • chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL)

  • follicular lymphoma

  • mantle cell lymphoma

Please note that this trial is currently only recruiting people who have mantle cell lymphoma (MCL).

Recruitment start: 29 September 2017

Recruitment end: 30 September 2024

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Professor Karl Peggs

Supported by

Autolus Ltd

University College London (UCL)

National Institute for Health Research (NIHR)

Last reviewed: 29 Sept 2024

CRUK internal database number: 15104

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