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A trial looking at guadecitabine with cisplatin and gemcitabine for advanced solid tumours (SPIRE)

Overview

Cancer types:

All cancer types, Bladder cancer

Status:

Results

Phase:

Phase 1/2

Details

This trial looked at adding a drug called guadecitabine to cisplatin and gemcitabine chemotherapy. It included people with any solid tumour. And part of the trial included people with bladder cancer who were due to have surgery.

A in this trial was any cancer apart from . An advanced solid tumour is a cancer that has spread or continued to grow despite treatment.

This trial was open for people to join between 2016 and 2019. The team published the results in 2021.

Cancer Research UK supports this trial.

Recruitment start: 5 May 2016

Recruitment end: 26 September 2019

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Dr Simon Crabb

Supported by

Cancer Research UK

Experimental Cancer Medicine Centre (ECMC)

NIHR Clinical Research Network: Cancer

Southampton University Hospitals NHS Trust

Other information

This is Cancer Research UK trial number CRUKD/16/004.

Last reviewed: 2 September 2021

CRUK internal database number: 13893

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