A trial looking at genetic factors in people having chemotherapy for bowel cancer

Cancer type:

Bowel (colorectal) cancer
Colon cancer
Rectal cancer





This trial looked at the genetic material (DNA) of people who had chemotherapy for advanced bowel cancer. This was to see if it affected how well they responded to treatment.

More about this trial

Chemotherapy is the main treatment for people with advanced bowel cancer. It works well for some people, but unfortunately not so well for others. There are a number of theories about why this happens, but no one is quite sure at the moment.

There is increasing evidence about how genes Open a glossary item affect the chances of developing cancer. And how they can affect people's response to treatments like chemotherapy. Doctors hope that in the future they will increasingly be able to tailor treatments according to people's genetic make up.

The aim of this trial was see if researchers could identify any common factors or genetic faults in people who respond well to chemotherapy, compared to those who don’t.

Summary of results

We have contacted the trial team who have told us that it is unlikely that the results from this trial will be published.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Prof Angela Cox
Dr Maria Marples

Supported by

Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
Weston Park Hospital Cancer Appeal fund

If you have questions about the trial please contact our cancer information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Over 60,000 cancer patients enrolled on clinical trials in the UK last year.

Last reviewed:

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