"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”
A trial of pemetrexed or etoposide with cisplatin and radiotherapy for locally advanced non small cell lung cancer (PROCLAIM)
This trial compared pemetrexed or etoposide alongside cisplatin and radiotherapy for non small cell lung cancer.
It was open to people with non small cell lung cancer that had grown into surrounding tissues (
More about this trial
Radiotherapy and chemotherapy are some of the usual treatments for non small cell lung cancer (NSCLC) if it is not possible to have surgery to remove it.
Doctors didn’t know which combination of chemotherapy drugs worked best in this situation but it usually included a
The aims of the trial were to:
- find out which treatment worked best for locally advanced non small cell lung cancer
- learn more about the side effects
Summary of results
The trial team found that having pemetrexed, cisplatin and radiotherapy did not work better than having etoposide, cisplatin and radiotherapy for locally advanced non small cell cancer.
Results of the trial were published in 2016. This explained that the trial was stopped after a review by the committee that monitors the safety and design of the trial (the
The committee looked at the results after people had finished all their treatment. These results suggested that it was very unlikely this trial would be able to show that having pemetrexed worked better than etoposide. So they decided it was best that no more people should take part.
555 people did take part in the trial. They were put into 1 of 2 groups at random.
- 272 had etoposide, cisplatin and radiotherapy
- 283 had pemetrexed, cisplatin and radiotherapy
People in the etoposide group had:
- 2 cycles of treatment with etoposide and cisplatin alongside radiotherapy
- 2 further cycles of treatment with chemotherapy that included a platinum drug such as cisplatin or carboplatin
People in the pemetrexed group had:
- 3 cycles of treatment with pemetrexed and cisplatin alongside radiotherapy
- 4 further cycles of pemetrexed
The researchers looked at how long people lived for after treatment (overall survival). They found that on average, this was:
- 25 months in the etoposide group
- just under 27 months (26.8 months) in the pemetrexed group
So although the above results show a very small difference in survival, it was not statistically significant. This means the difference between the 2 groups could have happened by chance.
The side effects between the 2 groups were similar. But people who had etoposide had more problems with:
- a drop in the number of white blood cells (neutropenia)
- a drop in the number of
- inflammation of the lung tissue (pneumonitis)
The trial team concluded that having pemetrexed, cisplatin and radiotherapy did not improve overall survival compared with etoposide, cisplatin and radiotherapy.
We have based this summary on information from the research team. The information they sent us has been reviewed by independent specialists (
How to join a clinical trial
Dr Mayukh Das
Eli Lilly and Company Limited
Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer