A trial looking at cediranib and olaparib for women with womb cancer (COPELIA)

The following bullet points list the entry conditions for this trial. Talk to your doctor or the trial team if you are unsure about any of these. They will be able to advise you.

Who can take part
You may be able to join this trial if all of the following apply:

• you have womb (endometrial) cancer
• your cancer continued to grow or spread to other parts of the body after treatment with a platinum chemotherapy that you had in the past year
• you have at least 1 area of cancer that can be seen and measured on a scan
• you have satisfactory blood tests results
• your liver, heart and kidneys are working well
• your thyroid is working well
• you can swallow and absorb tablets
• you are well enough to carry out all your normal activities, apart from heavy physical work (performance status 0 or 1)
• you are at least 16 years old
• you are willing to stop eating grapefruit or grapefruit juice during treatment and for a month afterwards
• are willing to use reliable contraception during treatment and for 6 months afterwards if there is any possibility you could become pregnant

Who can’t take part
You cannot join this trial if any of these apply.

Cancer related
You:

• have cancer spread to the brain that this isn’t controlled
• have moderate or severe side effects from previous chemotherapy, apart from hair loss
• have had chemotherapy, radiotherapy, surgery or a tumour embolisation in the last month
• are currently having cancer treatment
• have had olaparib, cediranib or any other similar drug
• have, or your doctor thinks you may have, acute myeloid leukaemia (AML) or myelodysplastic syndrome (MDS)
• have had another cancer in the past 5 years apart from carcinoma in situ of the cervix and breast, basal or squamous cell skin cancer or any other cancer that has been successfully treated

Medical conditions
You:

• have had an experimental treatment in the past month
• have fits (seizures) that aren’t controlled
• have an infection that isn’t controlled
• have high levels of protein in your urine
• take herbal supplements and you can’t stop them during treatment and for a month afterwards
• have taken drugs that affect enzymes called CYP3A in the past 2 to 5 weeks (your doctor can tell you more about this)
• have bowel problems such as a blockage (obstruction) or an abnormal passage (fistula) in the bowel or between the bowel and other organs
• have heart problems such as hypertension that isn’t controlled, an abnormal heart rhythm (arrhythmia) or you have had a heart attack in the past 3 months
• have HIV
• have hepatitis B or hepatitis C
• have had a bone marrow transplant from a donor (allogenic bone marrow transplant)
• have any other serious medical problem or mental health condition that doctors think could affect you taking part  

Other
You:

• are pregnant or breastfeeding  
• are sensitive to paclitaxel, olaparib, cediranib or anything they contain