
"I am glad that taking part in a trial might help others on their own cancer journey.”
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
Palbociclib, everolimus, abemaciclib and capivasertib are all types of targeted drugs. They are called cancer growth blockers. They block signals that cancer cells use to divide and grow.
Palbociclib, everolimus and abemaciclib are usual treatments for some types of advanced breast cancer.
Please note: currently doctors are only looking for people to join the parts of the trial looking at AZD9833, everolimus and capivasertib. This is part E, I and J.
The main aims of this trial are to:
This is an international phase 1 trial. Researchers hope that up to 340 people worldwide and 35 people from the UK will agree to take part.
There are 10 parts to this trial. The following parts are open to recruitment:
The following parts are closed to recruitment:
Part E
In Part E you have AZD9833 and everolimus. You have both treatments as tablets that you take in the morning, with or without food.
First you take one dose of everolimus alone. After 7 days, you start taking AZD9833 and everolimus tablets every day. This continues for as long as the treatment is helping you and the side effects aren’t too bad.
Part I and J
You have AZD9833 and capivasertib. Researchers hope that around 24 people will join part I and J.
The first few people have a,low dose of AZD9833 and capivasertib. If they don’t have any serious side effects, the next few people have a higher dose. This continues until doctors find the best dose of AZD9833 and capivasertib.
You take AZD9833 tablets every day. Capivasertib come as tablets that you take twice a day, for 4 days. You then have a break of 3 days and then start taking capivasertib in the same way.
Tissue and blood sample
The trial team ask you for a tissue sample of your cancer. This can be from when you had a biopsy or surgery to remove the cancer (archival tumour sample).
They may also ask you to give up to 3 new tissue samples (fresh tumour biopsies). You have them:
You don’t have to agree to give new tissue samples if you don’t want to. You can still take part in this trial.
You also have extra blood tests as part of this trial. Where possible, you have them at the same time as your routine blood tests. Doctors want to:
You have the extra blood tests at set times during this trial.
During treatment, you see the trial team regularly. How often you see them depends on when you join the trial.
You have regular tests during treatment. The tests you have include blood tests, physical examinations, and heart traces.
You also have a CT scan or MRI scan every 8 weeks, for six months. You then have a CT scan or MRI scan every 3 months. This continues for as long as the treatment is helping you and the side effects aren’t too bad.
When you finish treatment, you might see the trial team after one week, 2 weeks and a month. You have blood tests, a heart trace and a physical examination. You may continue to see the trial team afterwards if you still have side effects from treatment.
We have information about the side effects of:
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Richard Baird
AstraZeneca
Freephone 0808 800 4040
"I am glad that taking part in a trial might help others on their own cancer journey.”