A trial looking a lenvatinib and pembrolizumab for people with womb cancer (KEYNOTE-775)

• you have womb cancer that has come back (recurrent) or spread to other parts of the body (metastatic) 
• your cancer got worse after treatment with a platinum chemotherapy such as cisplatin or carboplatin 
• there is a suitable tissue sample available (archival tumour sample) that doctors can use to look for certain changes (or you are willing to have a new sample taken)
• you have at least 1 area of cancer that can be seen and measured on a scan 
• you are well enough to carry out your normal activities, apart from heavy physical work (performance status of 0 or 1) and this hasn’t changed in the past week 
• you have satisfactory blood tests results
• your heart is working well 
• you are at least 18 years old
• you are willing to use reliable contraception during treatment and for up to 6 months afterwards if there is any possibility that you could become pregnant 

• you have a type of womb cancer called carcinosarcoma, endometrial leiomyosarcoma or endometrial stromal sarcoma
• you have cancer spread in your brain unless you have had treatment, it hasn’t got worse in the past 4 weeks and you are no longer taking steroids
• your cancer has spread to a major blood vessel and your doctor thinks you have a high risk of bleeding 
• you have had a large bleeding from your cancer in the past 2 weeks 
• you have had more than 1 chemotherapy regimen that included a platinum drug unless you had it before or after your main treatment (adjuvant or neoadjuvant treatment)
• you have had chemotherapy, surgery or a targeted drug in the past 28 days
• you have had radiotherapy in the past 3 weeks, or 2 weeks if it was radiotherapy to help with symptoms (palliative)
• you have moderate or severe side effects from previous cancer treatment apart from hair loss and numbness or tingling in fingers and toes 
• have had pembrolizumab or any other similar drug 
• have taken part in another clinical trial looking at pembrolizumab and lenvatinib
• you have had another cancer in the past 2 years apart from early cancer (carcinoma in situ) of the cervix, breast and bladder or a non melanoma skin cancer 

Medical conditions
You cannot join this trial if any of these apply. You:

• are taking part in another clinical trial or have taken part in a trial looking at a new treatment (drug or device) in the past 4 weeks 
• have problems with your gut and you can’t absorb tablets 
• have had, or you currently have, lung problems such as pneumonitisthat needed treatment with steroids  
• have an abnormal opening (fistula) between organs or to the outside of your body 
• have coughed up a large amount of blood in the past 2 weeks 
• have heart problems such as high blood pressure (hypertension) that isn’t controlled, unstable angina, an abnormal heart rhythm or you have had a heart attack in the past 12 months 
• have had a stroke in the last year  
• have an infection and you need antibiotics that reach your whole body 
• have taken drugs that damp down your immune system (immunosuppressants) in the past week, unless it was a very small dose 
• have an autoimmune disease that needed treatment in the past 2 years, apart from treatment to replace something that the body makes such as insulin or thyroxine
• have had an organ transplant or a bone marrow or stem cell transplant from a donor (allogeneic transplant)
• have protein in your urine 
• have HIV 
• have hepatitis B or hepatitis C 
• have any other medical condition or mental health problem that the trial team think could affect you taking part 
• take an amount of drugs or drink an amount of alcohol that is a concern for the trial team 

• are pregnant or breastfeeding 
• have had a live vaccine in the past month 
• are sensitive to the drugs used in this trial or anything they contain