A trial of ribociclib alongside letrozole for advanced breast cancer (MONALEESA 2)

This trial was for women whose breast cancer had come back in the same place or had spread to another part of the body (advanced breast cancer).

Their cancer also had to be:

• hormone receptor positive

• HER2 negative

Hormone receptor positive means that breast cancer cells have receptors for the hormones oestrogen and progesterone. HER2 negative is when cancer cells don’t have receptors for the human epidermal growth factor (HER2).