
Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This trial is looking at a drug called AZD2014 for that have continued to grow despite all other
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The researchers are looking at a new drug called AZD2014. This is a type of biological therapy that works by blocking the action of a protein called mTOR, which helps to control how cells grow. Cells usually divide and grow in an orderly way. But in cancer cells, proteins such as mTOR can behave abnormally and this lets the cells grow out of control. If mTOR is blocked, this will hopefully stop or slow the growth of the cancer.
The aims of the trial are to
You can enter this trial if you
You cannot enter this trial if you
There are 2 parts to this phase 1 trial. Everybody taking part will have AZD2014.
In part A, the researchers are trying to work out the best dose of AZD2014 to give. The first few patients will have a low dose. If they don’t have any serious side effects, the next few patients will have a higher dose. And so on, until the researchers find the highest dose that can be given safely. This is called a ‘dose escalation study’. Once the highest safe dose has been found, some people may have lower doses so that the researchers can learn more about how lower doses work.
In part B, the researchers want to learn more about how AZD2014 works at the highest safe dose they found in part A, to look at different ways of taking the drug and to see the effect that food has on how much of the drug gets into your body.
You can take AZD2014 as a liquid or tablets that you swallow. In this trial, researchers are testing different ways of taking it. The trial team will explain exactly how and when you should take the liquid or tablets.
As long as you don’t have any bad side effects, you can carry on taking it for as long as it helps you.
The trial team will ask you to take part in some optional extra studies. These include
If you don’t want to give these extra samples for research, you don’t have to. You can still take part in the main trial.
You will see the trial doctors and have some tests before you start treatment. The tests include
The number of hospital visits you have depends on how you are taking AZD2014. The trial team will give you more information about this. You have regular blood tests and more ECGs. You have a CT or MRI scan every 8 weeks. And you may have 2 more PET scans in the first month of the study treatment.
Everybody taking part will go back and see the trial team a month after they finish treatment.
As AZD2014 is a new drug, there may be some side effects we don’t know about yet. The possible side effects that researchers already know about include
Your doctor will advise you to avoid or limit certain foods or supplements during the trial as they can affect how AZD2014 works. This includes grapefruit and Seville oranges.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Udai Banerji
AstraZeneca
Experimental Cancer Medicine Centre (ECMC)
If you have questions about the trial please contact our cancer information nurses
Freephone 0808 800 4040
Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.