
"I am glad that taking part in a trial might help others on their own cancer journey.”
This study will look for changes in blood and tissue samples before and after treatment for lung cancer, to try to find out how cancer cells stop themselves being harmed by treatment.
Doctors may use surgery, radiotherapy, chemotherapy or another type of drug that targets lung cancer to treat this disease. Your treatment will depend on your type and stage of lung cancer. If you have non small cell lung cancer, you may have a combination of these. If you have small cell lung cancer, you would usually have chemotherapy.
We know from research that cancer cells can become 'resistant’ to treatment. In lung cancer for example, cancer cells can sometimes reduce the concentration of the drug inside them, and repair DNA damage. And, develop changes in the genes in cancer cells that prevent the treatment from working.
Understanding why resistance happens will help develop improved treatment for lung cancer. This study is looking at genes and proteins in cancer cells in the blood and cancer tissue of people having lung cancer treatment such as chemotherapy containing platinum drugs. The main aim of this study is to find out why lung cancer often becomes resistant to treatment.
You will not get any direct benefit from taking part in this study, and it will not change your treatment in any way. But the results of the study will be used to help people with cancer in the future.
You can enter this study if you
You cannot enter this study if you
This study will recruit up to 1,200 people. Everyone will give a blood sample (between 2 and 4 teaspoons) and permission for the study team to
You do not have to join the next part of the study if you don’t want to. If you would like to, you will
The study team will look at these samples to find out how genes and proteins in cancer tissue change after chemotherapy. They will then check these findings against results from the stored samples and medical information.
Throughout the study you will remain under the care of your regular cancer specialist.
Where possible, you will give your study blood samples at the same time as your routine blood samples.
If you give any extra biopsies or fine needle aspirates, you may need to make extra hospitals visits to the Christie Hospital in Manchester. The samples would be taken before, during treatment and if your cancer comes back. The study team will tell you about any hospital visits you have to make.
You may have a small bruise where you gave your blood sample.
If you have biopsies for the study, the side effects will depend on the type of biopsy you have. You may have
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Fiona Blackhall
Experimental Cancer Medicine Centre (ECMC)
The Christie NHS Foundation Trust
Freephone 0808 800 4040
"I am glad that taking part in a trial might help others on their own cancer journey.”