"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”
A study to learn more about the causes of myeloproliferative disorders
Cancer type:
Blood cancers
Myelofibrosis
Polycythaemia
Thrombocythaemia
Status:
Open
Phase:
Other
This study is to see if there is a link between proteins called tyrosine kinases and the abnormal production of blood cells.
(‘MPDs’) are a group of conditions where your makes too many . Rarely, these conditions may develop into leukaemia.
If doctors understood more about how MPDs develop, they may be able to improve treatment for this group of conditions. Scientists think that MPDs develop because proteins called act as ‘growth factors’ and tell cells to keep on dividing. This study will test your white blood cells for tyrosine kinases. And look for any features or damage which may make them keep on dividing.
The aim of this study is to try to explain how MPDs develop. And to use this information to develop new treatments in the future. You will not have any direct benefit from taking part in this study, and it is unlikely to change your treatment plan in any way. But the results of the study will be used to help people in the future.
Who can enter
You can enter this study if you
- Have, or your doctor thinks you may have, a
myeloproliferative disorder - Are at least 18 years of age
You cannot enter this study if you have
- Already had a stem cell transplant
- Had interferon treatment in the last year
Trial design
This study hopes to recruit as many people as possible with a . Everyone talking part in the study will give a blood sample.
If you are due to have a , you will also give a small sample of for the study.
Hospital visits
You will give your study blood sample when you have your next routine blood test. And your bone marrow sample when you are due for your bone marrow test. So you will not need to make any extra hospital visits for this study.
Side effects
As you are having one or both of these tests anyway, you will not have any extra side effects from taking part in this study.
You may have a small bruise where you had your blood test. If you have a bone marrow test, your hip may ache for a couple of days. You may need to take some mild painkillers for this.
Location
Southampton
Recruitment start:
Recruitment end:
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.
Chief Investigator
Professor N.C.P. Cross
Dr A.S Duncombe
Supported by
Bloodwise
Experimental Cancer Medicine Centre (ECMC)
University Hospital Southampton NHS Foundation Trust
Questions about cancer? Contact our information nurses
Freephone 0808 800 4040
Last review date
CRUK internal database number:
1615
Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.
Wendy took part in a new trial studying the possible side effect of hearing loss
Last reviewed:
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