A study to find genes that might increase or reduce the risk of bowel cancer (CORGI 2)

We know from research that certain genetic factors you inherit from your parents may affect your risk of getting tumours in your bowel. This includes non cancerous (benign ) tumours such as polyps  and adenomas, as well as bowel cancer.

In this study, the researchers will look at the genes of a large number of people in 3 groups. They will look for common genetic factors that may increase or reduce the risk of developing bowel cancer.

The first group of people have, or have had:

• bowel cancer
• a non cancerous bowel tumour such as polyps
• another cancer that might be related to bowel cancer

This is the index patient group.

The second group are relatives by birth (blood relatives) of the index patient group.

The third group called the control group, are people who don’t have cancer.

The aims of the study are to:

• identify genes that might increase or decrease the risk of bowel cancer
• understand why bowel cancer might develop

Taking part in the study won’t affect any treatment you might have. You won’t benefit from taking part. The researchers hope that the results of this study will help people in the future.