Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.
A study to find genes that might increase or reduce the risk of bowel cancer (CORGI 2)
Researchers will look at samples of blood and tissue from people who have cancer and people who haven’t had cancer.
This study builds on a previous study of the research team called CORGI that is now closed.
More about this trial
We know from research that certain genetic factors you inherit from your parents may affect your risk of getting tumours in your bowel. This includes non cancerous (
In this study, the researchers will look at the genes of a large number of people in 3 groups. They will look for common genetic factors that may increase or reduce the risk of developing bowel cancer.
The first group of people have, or have had:
- bowel cancer
- a non cancerous bowel tumour such as polyps
- another cancer that might be related to bowel cancer
This is the index patient group.
The second group are relatives by birth (blood relatives) of the index patient group.
The third group called the control group, are people who don’t have cancer.
The aims of the study are to:
- identify genes that might increase or decrease the risk of bowel cancer
- understand why bowel cancer might develop
Taking part in the study won’t affect any treatment you might have. You won’t benefit from taking part. The researchers hope that the results of this study will help people in the future.
Who can enter
The following bullet points list the entry conditions for this study. Talk to your doctor or the study team if you are unsure about any of these. They will be able to advise you.
There are 3 groups in this study the:
- index patient group
- blood relative group
- control group
Index patient group
You may be able to join this study if you are older than 6 years and have or had one of the following:
- bowel cancer
- a non cancerous (benign) bowel condition such as polyps
- another cancer, such as endometrial cancer, that might be related to bowel cancer
Blood relative group
You may be able to join if you are over 18 years old and are a relative by birth (blood relative) of someone in the index patient group.
You may be able to join if you are over 18 years old and are:
- not a blood relative, such as sister in law or brother in law, of someone from the index patient group
- an individual who has never had cancer
Who can’t join this study
You can’t join this study as part of the control group if your father, mother, brother or sister (first degree relative) has or had bowel cancer.
The study team need 5,000 people to join.
You fill in a short questionnaire. The questions are about your:
- medical details
- family history
- diagnosis and hospital treatment, if relevant
You can ignore any question if you want to and not answer it.
You have a sample of blood taken. This can be done at the hospital by the doctor, nurse or member of the study team. Or your GP or Practice Nurse can take it.
If you have had cancer the study team will ask for a piece of tissue from when you were first diagnosed. They will also ask for a piece of tissue if in the future you have further surgery, tissue samples (
They may also ask if they can contact you about any future research which you might be able to take part in.
You don’t have to agree to the samples or the future research if you don’t want to.
There are no extra hospital visits if you take part in this study.
There are no side effects.
How to join a clinical trial
Cancer Research UK
University of Birmingham