This is a
phase 2 study. It is taking place in Europe and the UK. The researchers need 120 women to take part including 25 in the UK.
Treatment
Everyone has fulvestrant and palbociclib.
Palbociclib is a capsule. You have treatment over 4 weeks. You take palbociclib everyday for 21 days then you have a week off. Each 4 week period is a
cycle of treatment. The doctor or research nurse will give you a fresh supply of tablets each month.
You fill in a diary to note down when you take the capsules and include any side effects you might have.
You have fulvestrant as 2 injections – 1 into each buttock.
The first day of each treatment cycle is called day 1. In the first month of treatment, you have fulvestrant on:
Then you have it once a month every month.
You have treatment for as long as it is helping and the side effects aren’t too bad. You stop treatment if your cancer gets worse. Your doctor will then talk to you about other treatment options.
Blood samples for research
The researchers will ask you to give some extra blood samples. You have these at the same time as your routine blood samples if possible. They plan to use the samples to look for
biomarkers 
to predict who will benefit from treatment.