A study of DTP3 for advanced myeloma

Cancer type:

Blood cancers




Phase 1/2

This study was for people whose myeloma had come back or treatment had stopped working.

More about this trial

There are a number of ways to treat myeloma. But sometimes the myeloma comes back after treatment or stops responding to it.
So doctors are looking at new treatments to help this group of people. In this study, they looked at DTP3.
DTP3 is a targeted cancer drug. It kills myeloma cells but doesn’t affect normal cells. This meant it might have fewer side effects.                    
The main aims of the study were to:
  • find the best safe dose of DTP3
  • learn more about the side effects
  • find out what happened in the body
  • find how well DTP3 might work

Summary of results

The study team found that DTP3 could be used to treat people with myeloma that had come back or when treatment had stopped working. 
This study was open to people to join between 2016 and 2017.
These results were published in 2018. 
About this study
The team looked at 3 different doses of DTP3. 
3 people took part in this study. Each person had a different dose of DTP3. 
2 people had 1 cycle of treatment of DTP3 and 1 person had 3 cycles, each lasting 1 month. No one reported any side effects that might stop their treatment. 
Doctors look at substances in the urine and blood (biomarkers Open a glossary item) called free light chains and paraprotein. This helps to find out how well treatments might work for myeloma. 
When the researchers looked at these they found that for 1 person these had decreased in the blood. This was in keeping with their myeloma which was not getting any worse. 
This person’s free light chains and paraprotein stayed this way for 3 treatment cycles of DTP3 before their myeloma started to get worse again. 
The team looked at blood test results and bone marrow Open a glossary item test results to find what was happening in the body. They found that DTP3 triggered programmed cell death (apoptosis Open a glossary item) for myeloma cells but not for healthy cells. This meant it killed myeloma cells but didn’t affect healthy cells. 
The study team concluded that these initial results are encouraging. And they are planning to do larger clinical trials to find how well DTP3 might work for people with myeloma. 
Where this information comes from
We have based this summary on information from the research team. The information they sent us has been reviewed by independent specialists (peer reviewed Open a glossary item) and published in a medical journal. The figures we quote above were provided by the trial team who did the research. We have not analysed the data ourselves.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Jane Apperley

Supported by

Imperial College London
Medical Research Council
NIHR Imperial Clinical Trial Facility

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Over 60,000 cancer patients enrolled on clinical trials in the UK last year.

Last reviewed:

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