
"I am glad that taking part in a trial might help others on their own cancer journey.”
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This study is looking at bortezomib for people with myeloma after they have had a transplant of their own stem cells ().
Doctors can treat myeloma with , followed by a transplant of the person’s own stem cells. We know that people who have a good response to their transplant may stay free of myeloma for longer.
Bortezomib is an anti cancer drug. We know from research that bortezomib can work well as a treatment for people with cancer.
The researchers think that people may have a better response to their stem cell transplant if they have bortezomib after it. If so, this may increase the amount of time they stay free of myeloma.
The aims of this trial are to find out
You can enter this trial if
You cannot enter this trial if you
This is a phase 2 study. It will recruit about 45 people.
Everyone will have bortezomib. You start bortezomib about 3 months after your stem cell transplant. You have it once a week for 4 weeks as an injection under the skin. Each 4 week period is called a cycle of treatment.
After 3 cycles of treatment, you have an assessment to see how your myeloma is responding. If the treatment is helping you and there aren’t any bad side effects you can have up to another 5 cycles, making a maximum total of 8 cycles.
If your myeloma has continued to grow you have no more treatment as part of this study. Your doctor will talk to you about what other treatments may be available to you.
Before you take part in the trial, and at times during it, you will have blood tests taken to measure the levels of myeloma proteins in your blood. Before you start treatment, then at 6 and 12 moths after your transplant, you will be asked to collect your urine for 24 hours. This is so the team can test for myeloma proteins in your urine. The hospital will provide all the information and equipment you need to do the 24 hour urine collection at home.
You fill in a questionnaire before you start treatment, during treatment and 4 weeks after finishing treatment. This will ask how you have been feeling and about any symptoms you have had. This is called a quality of life questionnaire.
You will see the doctor to have some tests before starting treatment. These include
You will have blood tests done every 4 weeks before each cycle of treatment.
At 6 months and 1 year after treatment you will have
The side effects of bortezomib can include
We have more information about bortezomib in our cancer drugs section.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor Kwee Young
Experimental Cancer Medicine Centre (ECMC)
Janssen-Cilag
NIHR Clinical Research Network: Cancer
University College London (UCL)
Freephone 0808 800 4040
"I am glad that taking part in a trial might help others on their own cancer journey.”