A study looking at the management of breast cancer that has come back in the same breast or nearby areas (MARECA)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Breast cancer





This study is looking at the tests and treatment for people whose breast cancer has come back in the same breast or nearby area. 

It is for people whose breast cancer has come back in the same breast, chest wall or nearby lymph nodes Open a glossary item. This is locoregional breast cancer recurrence Open a glossary item.

The aim is to make recommendations for the best care and treatment of people with this type of breast cancer recurrence.

Who can enter

The following bullet points are a summary of the entry conditions for this study. Talk to your doctor or the study team if you are unsure about any of these. They will be able to advise you. 

Who can take part

You may be able to join this study if all of the following apply. You:

  • have had treatment for invasive breast cancer or ductal carcinoma in situ (DCIS) with the aim to cure
  • have within the past 6 months been diagnosed with breast cancer (invasive breast cancer or DCIS) in the same breast or chest wall and or nearby lymph nodes 
  • had surgery to remove the original cancer at least 3 months ago
  • are at least 18 years old

Who can’t take part

You cannot join this study if any of these apply. 

  • Your original breast cancer had spread to another part of the body (secondary breast cancer).  
  • You had cancer diagnosed in 1 breast. And you now have cancer diagnosed in the other breast. 
  • You have secondary breast cancer. But there is no cancer in the breast, chest wall or lymph nodes. 
  • You have a rare cancer of the lining of the blood vessels or lymph vessels (angiosarcoma).
  • You have another type of cancer and didn’t have treatment with the aim to cure. 
  • You had surgery to the breast for another type of breast condition that wasn’t cancer or for a soft tissue sarcoma Open a glossary item of the breast. Or you haven’t had surgery for a primary breast cancer Open a glossary item in the same breast. 

Trial design

The study team need up to 500 people to take part. 

A member of your health care team will look at your medical records for the following information:

  • the date of diagnosis of the cancer coming back in the same area
  • general details about your medical history
  • any tests, scans, or treatments you had for the original breast cancer and the breast cancer that has come back

They will continue to look at your medical records for up to 5 years after your diagnosis. 

Tissue sub study
The team ask for your permission to look at tissue samples (biopsies Open a glossary item) from:

  • when you were first diagnosed 
  • when your cancer came back

They plan to use these for future research into breast cancer.

You don’t have to agree to this if you don’t want to. You can still take part in the main study.

Hospital visits

There are no extra hospital visits for this study. 

Side effects

There are no side effects if you take part in this study. 

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Mr Baek Kim

Supported by

Association of Breast Surgery (ABS)
Leeds Teaching Hospitals NHS Trust
Leeds Hospitals Charity

If you have questions about the trial please contact our cancer information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Last reviewed:

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