A study looking at PET-CT scan in men with prostate cancer and a DNA gene mutation (GENPET)

The following bullet points list the entry conditions for this study. Talk to your doctor or the study team if you are unsure about any of these. They will be able to advise you.

You may be able to join this study if you are a patient at the Royal Marsden Hospital. You are at least 18 years old and have prostate cancer with a change (mutation) in one of the following DNA Repair genes:

• BRCA1
• BRCA2
• MSH2
• MSH6
• MLH1
• PMS2
• CHEK2
• PALB2
• ATM

​Your doctor will know if your cancer has one of these gene changes. 

And you are in one of the following situations:

• You are newly diagnosed with prostate cancer.
• You were treated with radical surgery or radiotherapy more than 6 months ago and your blood tests show your cancer might be growing and you are not currently having hormone treatment or chemotherapy.
• You are on active surveillance and your PSA is doubling every 6 months or less, or a scan or tissue sample (biopsy) shows your cancer might be growing.

You cannot join this study if any of these apply. You:

• have prostate cancer that has spread outside of the prostate gland (locally advanced or metastatic prostate cancer)
• have had cancer treatment in the last 6 months
• are having any experimental drug treatment
• are taking steroids
• have had any other type of cancer in the last 5 years apart from non melanoma skin cancer
• have had certain inflammatory conditions such as inflammatory bowel disease or sarcoidosis
• have had certain infections such as tuberculosis (TB)
• are not able to have an MRI scan for any reason such as having a pacemaker, metal surgical clips, or a fear of closed spaces (claustrophobia)