“I think it’s really important that people keep signing up to these type of trials to push research forward.”
A study looking at new types of MRI scans to see how chemotherapy affects bowel cancer cells
This study used 2 types of MRI scan to look at changes in the blood supply to cancer cells.
It was for people who had chemotherapy for bowel cancer that had spread (advanced bowel cancer).
Cancer Research UK supported this study.
This study was open for people to join between 2011 and 2013.
The trial team have submitted these results to be published in a journal.
More about this trial
Doctors can treat advanced bowel cancer with chemotherapy. They might also use targeted cancer drugs that block cancers growing new blood vessels. But these drugs don’t help everybody.
Researchers want to find out how to tell in advance whether a patient is likely to benefit from them.
Before looking at the effect of a combination of chemotherapy and a targeted drug, researchers wanted to learn more about the effect that chemotherapy alone had on cancer cells.
In this study, they used 2 types of MRI scan called dynamic contrast enhanced MRI (DCE MRI) and diffusion weighted imaging MRI (DWI MRI).
DWI MRI shows changes to cancer cells and DCE MRI can provide information about the blood supply to the cancer.
The researchers wanted to find out if any changes they saw on the scans related to how well people do after having chemotherapy.
They also took extra blood samples to see if proteins and cells in the blood (
Summary of results
- structure of blood vessels surrounding the cancer
- total size (volume) of cancer in the liver
- numbers of cells in the cancer (cell density)
- if new blood vessels were growing
- how many cells had undergone programmed death (
- 5 people was considerably higher than before treatment
- 5 people was considerably lower than before treatment
- 10 people it didn’t change much
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor Gordon Jayson
Cancer Research UK
Experimental Cancer Medicine Centre (ECMC)
National Institute for Health Research Cancer Research Network (NCRN)
The Christie NHS Foundation Trust