“I think it’s really important that people keep signing up to these type of trials to push research forward.”
A study looking at metformin before surgery for womb cancer (PREMIUM)
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This study looked at the diabetes drug metformin for womb cancer and a condition affecting the lining of the womb called endometrial hyperplasia.
More about this trial
Endometrial hyperplasia is a precancerous condition that increases your risk of womb cancer.
Doctors use a drug called metformin to treat diabetes. When this trial was done, laboratory research had shown that metformin may help slow down the growth of some cancers, including womb cancer.
In this study, some women had metformin tablets before their operation, and some women had a placebo (dummy) tablets.
The research team measured the amount of a protein called Ki-67 in womb cancer cells before and after metformin (or placebo) treatment. Cells produce more Ki-67 when they are growing more quickly. So a drop in the amount of Ki-67 would suggest that the cells are dividing and growing more slowly.
The main aim of the study was to see if having metformin before surgery helps slow the growth of womb cancer or endometrial hyperplasia.
Summary of results
- 45 had metformin tablets
- 43 had placebo (dummy) tablets
Everyone taking part had treatment every day for up to 5 weeks. Women in the metformin group had treatment for an average of 21 days. And women in the placebo group had treatment for an average of 22 days.
How to join a clinical trial
Dr Emma Crosbie
Central Manchester University Hospital NHS Foundation Trust
NIHR Clinical Research Network: Cancer