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A study looking at an intestinal microbiota transplant before a donor stem cell transplant for blood cancer (MAST)

Overview

Cancer types:

Acute leukaemia, Acute lymphoblastic leukaemia (ALL), Acute myeloid leukaemia (AML), Blood cancers, Chronic leukaemia, Chronic myeloid leukaemia (CML), Myelodysplastic syndrome (MDS)

Status:

Open

Phase:

Phase 2

Details

This study is looking at a type of treatment called intestinal microbiota transplant. It’s a way of encouraging more variety in gut bacteria.

It’s open to people having a with donor cells for:

  • acute myeloid leukaemia (AML)

  • acute lymphoid leukaemia (ALL)

  • acute leukaemia of ambiguous lineage

  • myelodysplastic syndrome (MDS)

  • chronic myelomonocytic leukaemia (CMML)

  • chronic myeloid leukaemia (CML)

Recruitment start: 1 May 2024

Recruitment end: 1 October 2025

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Dr Jiri Pavlu

Professor Julian Marchesi

Supported by

Imperial College London

Medical Research Council (MRC)

Last reviewed: 7 May 2025

CRUK internal database number: 19681

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