A study looking at a new test called FIT to look for signs of bowel cancer (NICE FIT)

Please note - the main part of this trial is now closed. Only the biomarker sub study and the multisampling sub study are open for recruitment. 

Researchers hope that around 5,500 people from England will take part in this study. 

You do the FIT at home, before having the colonoscopy. You are sent a kit and a leaflet which explains how to do the test. Once you have tested the poo, you send it to the laboratory using a prepaid envelope. 

The colonoscopy you have is the same as if you weren’t taking part in this study. Your doctor or nurse can tell you what to expect. Taking part in this study will not delay you having the colonoscopy. The results of the FIT test will not affect your care or be given to you.

Biomarker sub study
Researchers need up to 2,000 people who are taking part in the main study, to join this sub study. 

Everyone taking part has a blood test and gives a tissue sample. You give them when you are at the hospital having a colonoscopy. 

Researchers want to look for bowel cancer DNA in your blood and tissue sample. This is called circulating tumour DNA. 

Multisampling sub study 
Researchers hope that between 500 and 1,000 people who are taking part in the main study will agree to join this sub study. 

Everyone taking part gives 4 poo samples, instead of one. You are sent 4 kit tests from different brands. You do the test at home and send it back to the laboratory using the prepaid envelope. The study team will send you clear instructions on how to do the tests. 

Researchers want to find out whether there are any differences between the 4 kit brands.