“I was keen to go on a clinical trial. I wanted to try new cancer treatments and hopefully help future generations.”
A study looking at a new device to help surgeons know if they have removed all the breast cancer
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This study looked at a device called Cerenkov Luminescence Imaging (CLI) Specimen Analyser to help surgeons tell if they have removed all of the cancer.
More about this trial
- CLI can help surgeons see all of the cancer during surgery
- it would be useful to do a larger trial looking at CLI during breast surgery
Summary of results
The research team found that using the CLI Specimen Analyser during surgery could help surgeons see if they had removed all the cancer.
They recruited patients between 2014 and 2016, and published the results in 2017.
Everyone taking part had an injection of a radioactive tracer called 18F-FDG, the same tracer used to detect cancer on PET scans. They then had their operation about 45 to 60 minutes later.
The research team altered the various settings on the CLI equipment during the operations for the first 10 people. This is called optimisation. They did this to make sure they could see the cancer cells as clearly as possible. The most accurate settings were then used during the operations for the next 12 people.
The surgeons could see the cancer cells using the CLI Specimen Analyser in 10 out of these 12 people. It is possible they didn’t see cancer in the other two people because it was too small. Or because it had been too long since the patient had had the 18F-FDG injection.
The research team compared the results from the CLI Specimen Analyser with results from the laboratory (histopathology) and other scans. They also compared the results and conclusions from different doctors. They found they were similar.
The research team concluded that using 18F-FDG and the CLI Specimen Analyser during surgery for breast cancer could help them see if they had removed all of the cancer.
They suggest that a larger trial is done to find out more about how well it works. And whether it can help reduce the number of people who need a second operation.
We have based this summary on information from the research team. The information they sent us has been reviewed by independent specialists (
How to join a clinical trial
Professor Arnie Purushotham
Experimental Cancer Medicine Centre (ECMC)
Guy's and St Thomas' NHS Foundation Trust
King's College London
Lightpoint Medical Ltd