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A study looking at a drug called INCB057643 for cancers affecting the bone marrow

Overview

Cancer types:

Blood cancers, Myelodysplastic syndrome (MDS), Myelofibrosis, Polycythaemia, Thrombocythaemia

Status:

Closed

Phase:

Phase 1

Details

This study is looking at a new drug called INCB057643 to treat cancers that affect how well the bone marrow works.

It is open to people who have:

  • myelofibrosis

  • features of myelodysplastic syndrome and myeloproliferative neoplasm when diagnosed. This is myelodysplastic/myeloproliferative overlap syndrome.

  • myelodysplastic syndrome

  • essential thrombocythaemia

Recruitment start: 1 September 2020

Recruitment end: 2 October 2025

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Dr Emma Searle

Supported by

Incyte Corporation

Last reviewed: 05 Jan 2026

CRUK internal database number: 18044

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