A study looking at a blood test to diagnose ovarian cancer

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Ovarian cancer

Status:

Closed

Phase:

Pilot

This study is looking at a blood test called HE4 to diagnose ovarian cancer.

The study is open to women who go to the gynaecology clinic at Central Manchester University Hospitals.

More about this trial

To help diagnose ovarian cancer doctors use a blood test called CA125. If your CA125 is high it might mean you have ovarian cancer. But CA125 can be high in other medical conditions not just ovarian cancer. So if you have a high CA125 you have further tests to find out.

To try and avoid this, doctors would like to find a blood test that is more precise than the CA125 test in diagnosing ovarian cancer. A better test could also mean that ovarian cancer is diagnosed and treated earlier.

Research in hospitals using the HE4 blood test shows that it is more accurate than CA125 in identifying ovarian cancer.

CA125 blood samples ordered by GPs in Manchester go to The Central Manchester Foundation Trust (CMFT) laboratories. They carry out the HE4 test as well as the CA125 test.

In this study the researchers want to follow up all the women whose blood sample had the CA125 and HE4 test done.

The aim of the study is to compare the CA125 and the HE4 test to find out which is better at identifying ovarian cancer.

Who can enter

The following bullet points list the entry conditions for this study. Talk to your doctor or the study team if you are unsure about any of these. They will be able to advise you.

Who can take part

You may be able to join this study if all of the following apply. Your GP has:

taken a blood sample for CA125
referred you to the gynaecology clinic at the Central Manchester University Hospital for further assessment

Trial design

A member of the study team will ask you some questions about your medical history and lifestyle. This should take no more than 10 minutes.

They will also ask to look at your hospital notes. They want to find out what tests were done and the results.

Hospital visits

There are no extra hospital visits. The team will ask for 10 minutes after one of your regular hospital appointments.

Side effects

There are no side effects.

Recruitment start:

03/04/2018

Recruitment end:

31/10/2019

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

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Questions to ask your doctor about clinical trials

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Emma Crosbie

Supported by

University of Manchester

Wellbeing of Women

If you have questions about the trial please contact our cancer information nurses

Freephone 0808 800 4040

Email

Last review date

4 November 2019

CRUK internal database number:

15703