A study to learn more about how prostate cancer grows and how it could be treated in future (ProMPT)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Prostate cancer





This study is looking at medical information and samples from men with and without prostate cancer to learn more about the disease and how possible new treatments could be developed.

There are many things that may affect whether a man gets prostate cancer, at what age they get it, and how quickly the cancer will grow. Researchers in this study are trying to work out which aspects of our biological and genetic make up might affect these factors.

To collect this information, they will recruit men with and without prostate cancer. They will find out more about their health, lifestyle and family medical history. And collect samples of blood and any prostate tissue they may have had removed in the past, or will have removed in the future. They hope that having more knowledge about this will help doctors better understand the causes of prostate cancer, and one day help them to design better tests and treatments.

You will not have any direct benefit from taking part in this study. But the results of the study will be used to help men in the future.

Who can enter

You may be able to enter this study if you

  • Are seeing doctors at one of the hospitals taking part in the study
  • Have prostate cancer that has been confirmed by a biopsy, or you have had tests for prostate cancer, but these came back clear

You will not be able to enter this study if you have any other serious health conditions that could affect the results of the study. You can ask your doctor more about this.

Trial design

Everyone who says they are interested in taking part in this study will have a short interview with research staff. They will ask you questions about yourself and any history of cancer in your family. They may also ask you to complete some detailed questionnaires about your health, diet and lifestyle. And give a blood sample (about 10 teaspoons) and a urine sample.

The team will not process any of these samples until you have had a chance to think further about whether or not you want to fully take part. If you decide you want to, they will store these samples so that they can be used for future research.

If you continue to come back to hospital for other appointments, the team may ask if you would be willing to give more blood and urine samples at these visits. They will look at how different chemicals and proteins in these samples change over time, and whether this can help in understanding prostate cancer, if you have it.

The research team will ask you to agree to the study of any stored samples of prostate tissue that you have had removed, or any you may have removed in the future. They will look at how genes work in the prostate tissue, which may help with designing future treatments.

They will also ask if they can gather information about your medical history from your medical records and other medical databases. They will then be able to learn more about how your health relates to genes and other biological factors.

The team will study chemical molecules that may be linked to an increased risk of cancer. This will include tests on DNA, proteins and other chemicals. They will compare the DNA from men with and without prostate cancer to try and find genes that may (along with other things) play a part in cancer developing.

They will store the genetic information from your sample in an international library or database. Your genetic information will be coded and stored separately from your personal information so that scientists cannot link any data they have to who you are.

Other research will include looking for factors (biomarkers) to help researchers design better treatments for prostate cancer.

Hospital visits

You take part in this study when you are already at the hospital for other reasons. So you will not need to make any extra visits to take part.

Side effects

There should be no side effects from taking part in this study. You may have a small bruise where you gave your blood sample.

Because all the data in this study will be kept anonymously, the team will not give you any individual results from their findings. So taking part will not affect your treatment, future care or any life or medical insurance you may have.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Freddie Hamdy

Supported by

Experimental Cancer Medicine Centre (ECMC)
Medical Research Council (MRC)
NIHR Clinical Research Network: Cancer
National Cancer Research Institute (NCRI)
Northern and Bristol Prostate Cancer Collaborative (known as ProMPT)

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Keith took part in a trial looking into hormone therapy

A picture of Keith

"Health wise I am feeling great. I am a big supporter of trials - it allows new treatments and drugs to be brought in.”

Last reviewed:

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