
“I think it’s really important that people keep signing up to these type of trials to push research forward.”
This study compared 2 endoscopy procedures called radiofrequency ablation and argon plasma coagulation in people with Barrett’s oesophagus.
Barrett’s oesophagus is a change in the cells lining the food pipe (oesophagus). It can start after years of having stomach acid coming up into your food pipe (acid reflux).
Sometimes these cell changes can lead to cancer. So it is important to remove the affected tissue before cancer develops, or when it is at an .
Barrett’s oesophagus is usually treated during an endoscopy. The doctor uses a flexible camera to look inside the food pipe and remove the abnormal tissue.
But, sometimes the abnormal tissue cannot be completely removed. What remains may not have pre cancerous cells, but there is a risk of further pre cancer or early cancer developing.
There are 2 procedures to treat the lining of the food pipe:
Both work by gently burning the affected tissue and allowing the lining to heal as normal food pipe lining. They are both useful, but doctors don’t know which works best.
The main aims of this study were to:
The research team concluded that there was no difference between using radiofrequency ablation and argon plasma coagulation to treat people with Barrett’s oesophagus.
76 people took part in this study. They were put into 2 groups:
Everyone taking part had either radiofrequency ablation or argon plasma coagulation every 2 months, for 1 year.
People also had a drug to reduce the amount of acid produced by the stomach (a proton pump inhibitor) twice a day.
So far the following people have completed 1 year of treatment:
Researchers looked at people in both groups who still had Barrett’s oesophagus at the end of treatment. They found there was no difference between the 2 groups. But, there was only 76 people in this study so it was difficult for researchers to be sure.
Researchers also looked at the number of side effects from radiofrequency ablation and argon plasma coagulation. They found it was similar in each group.
The doctors interviewed 18 people who took part in the study. They asked:
They found that people:
The study doctors also asked 70 health professionals the best treatment for Barrett’s oesophagus. They preferred endoscopy, and suggested doing a study comparing surgery to endoscopy in people with extensive or
Researchers want to confirm these results by doing another study with a large number of people.
We have based this summary on information from the research team. As far as we are aware, the information they sent us has not been reviewed independently () or published in a medical journal yet. The figures we quote above were provided by the research team. We have not analysed the data ourselves.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor John de Caestecker
NIHR Research for Patient Benefit (RfPB) Programme
Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
University Hospitals of Leicester NHS Trust
University of Leicester
If you have questions about the trial please contact our cancer information nurses
Freephone 0808 800 4040
“I think it’s really important that people keep signing up to these type of trials to push research forward.”