A study to find out more about prostate cancer (ReIMAGINE Prostate Cancer Risk)

Cancer type:

Prostate cancer

Status:

Open

Phase:

Other

This study is collecting samples to carry out detailed testing in men having tests for suspected prostate cancer.

More about this trial

Researchers know that 1 in 3 men over the age of 50 have cancer cells in their prostate. But most will never know they have cancer and it won’t affect their quality of life Open a glossary item

or how long they live. But in some men, the cancer can grow quickly. These cancers are more likely to spread outside of the prostate.

At the moment there isn’t a way to tell the difference between prostate cancer that grows fast and those that grow slowly. So researchers are running this study to find out more. To do this, they plan to look at:

tissue samples (biopsies ) from the prostate
urine samples
blood samples
detailed images from scans

They’ll carry out very detailed testing on these. They want to find out more about:

how prostate cancer develops
why some prostate cancers spread to other parts of the body and others don’t
why treatment works for some prostate cancers and not for others

Researchers hope this could improve the diagnosis and monitoring of prostate cancer.

Please note, there won’t be a direct benefit if you take part in this study. But it might help other men with prostate cancer in the future.

Who can enter

The following bullet points list the entry conditions for this study. Talk to your doctor or the study team if you are unsure about any of these. They will be able to advise you.

Who can take part

You may be able to join this study if all of the following apply.

You have a PSA blood test result of 20 or less and you had this test done in the last 3 months.
You have had an MRI scan of your prostate.
The MRI scan shows a suspicious area that needs a prostate biopsy to confirm whether or not cancer there is cancer.
You haven’t had hormone therapy in the last 6 months.

Who can’t take part

You cannot join this study if any of these apply.

You:

can’t donate tissue, blood or urine samples
have already had treatment for prostate cancer including surgery, radiotherapy, chemotherapy, focal therapy such as HIFU, cryotherapy, Nanoknife or radiofrequency ablation, or other drug treatments
had a prostate biopsy less than 12 months before your MRI scan

Trial design

This study is taking place in the UK. The researchers need 1,000 men to join.

The study team might approach you:

when you are referred to hospital by your GP
on the day of your prostate MRI
after you have had an MRI scan and the doctors advise you to have a prostate biopsy

They’ll give you an information sheet about the study. But they’ll only invite you to join if the MRI recommends, and you decide to have a prostate biopsy. This isn’t an extra test. You have this even if you decide you don’t want to join the study.

Research samples

The doctors or study team will ask permission to collect 3 extra tissue samples when you have the biopsy. You also give blood and urine samples as well as access to medical information including images from your MRI scan. They plan to use the samples to look at bits of genetic material (DNA Open a glossary item

They’ll compare samples from men with and without prostate cancer to try and find out what plays a part in cancer developing.

They might also look for other genetic changes in the blood. They’ll tell you about any results that are important for you and your family if they find anything. If this is what you have agreed to beforehand.

Hospital visits

You shouldn’t need any extra hospital visits as a result of taking part in this study.

Follow up

The study team will follow you up for a long period of time if you agree. You won’t have any extra hospital visits. They’ll check your medical notes and records to see how you are getting on. This will help researchers to understand more about the long term outcomes of men with prostate cancer