A study looking at a fluorescent substance called EMI-137 to help doctors see bowel cancer during surgery

Cancer type:

Bowel (colorectal) cancer
Colon cancer

Status:

Results

Phase:

Other
This study was done to see if EMI-137 could make it easier for surgeons to see bowel cancer cells. It was for people due to have surgery to remove part of their bowel. 
 
The study was open for people to join in 2018 and 2019. The team published the results in 2022.
 

More about this trial

Doctors often treat bowel (colorectal) cancer with surgery. They try to remove all of the cancer and an area of healthy tissue around it. But sometimes it is difficult for doctors to see exactly where the cancer is. 

In this study, doctors used a fluorescent substance called EMI-137. They hoped it would make areas of cancer show up under a special light. They looked at the bowel and the nearby lymph nodes with the special light during surgery. 

The main aim of this study was to find out whether EMI-137 can help surgeons see areas of bowel cancer during the operation.
 

Summary of results

The research team found that EMI-137 can help surgeons see areas of bowel cancer in some people.

Study design
A total of 9 people with colon cancer joined this study. They were between 67 and 77 years old and due to have surgery. 

They all had EMI-137 as a drip into a vein a few hours before their operation.

The surgeons then used a fluorescent light to look for cancer cells during surgery. 

Results
The surgeon could see cancer cells under the fluorescent light in 4 out of 9 people. It was less clear in the other 5 people.

They also looked at the cells in the laboratory. They found that EMI-137 binds to a protein called c-Met. There is often much more of the c-Met protein than usual in bowel (colorectal) cancer cells. It can help the cancer grow and spread.

No one taking part had and side effects from the EMI-137 injection.

Conclusion
The research team concluded that EMI-137 could help surgeons see areas of cancer in some people. They suggest more work is done to find out more about it and the best way to use it.

Where this information comes from    
We have based this summary on information from the research team. The information they sent us has been reviewed by independent specialists (peer reviewed Open a glossary item) and published in a medical journal. The figures we quote above were provided by the trial team who did the research. We have not analysed the data ourselves.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor David Jayne

Supported by

The Leeds Teaching Hospitals NHS Trust
University of Leeds
EMI Ltd

 

If you have questions about the trial please contact our cancer information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

15471

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Last reviewed:

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