Therapeutic Discovery Project Award
About this scheme
You should be:
- A scientist, clinician or health care worker with a salaried position for the full duration of the award
- Based at a UK university, medical school, hospital or research institution
Prior experience of working in drug discovery is not necessary, but an early interaction with a professional drug discovery partner will strengthen your application. We will also support collaborative projects between an academic partner and a commercial partner where appropriate. In some circumstances, non-UK based collaborators are accepted.
If you are unsure of your eligibility, please contact Discovery@cancer.org.uk
This scheme funds research at the early to mid-stage of drug discovery including identification and validation of molecules with therapeutic potential, further testing and development of these molecules etc. Sequential Project funding would be considered for the linear development of a therapeutic entity.
Examples of eligible studies include:
- Studies to identify potential therapeutic compounds including diversity screens, focused screen (virtual followed by biochemical screen), fragment-based screens (e.g. surface plasmon resonance (SPR) spectrometry, biolayer interferometry (BLI) and X-ray crystallography), as well as knowledge-based and de novo structure-based design
- Validation and testing to demonstrate that a compound has therapeutic potential for modification to an entity with properties suitable for clinical use
- Identification of therapeutic molecules e.g. screens, validation of molecules
- Re-positioning clinically validated therapeutic drugs or combinations of therapeutics with small molecule drugs (or other therapeutic modalities) in oncology indications
- Application of novel technologies to improve the efficacy of therapeutic drugs
- Development of a therapeutic agent such as an antibody or antibody drug conjugate and oncolytic viruses. This includes medicinal chemistry testing and development of a small molecule agent
- Additionally, affinity testing, toxicity studies and binding cascade of a therapeutic compound will also be considered
- Development and testing of cell-based therapies including chimeric antigen receptor therapy, modified T cells, vaccines, invariant natural kill cell therapy etc. as well as gene and protein therapy
This scheme does not fund:
- Preclinical development studies to initiate clinical trials (e.g. bulk synthesis/manufacture to GMP, toxicology to GCP). These may fall under the remits of the New Agents Committee and the Clinical Research Committee
- The development of novel delivery vectors and technologies. This may fall under the remit of the Multidisciplinary Award
- Basic immunology projects. These may fall under the remits of the Cancer Immunology Project Award
Funding support is provided for:
- Postdoctoral researchers
- Technical staff
- Associated running expenses
- Equipment up to £15,000, if required for the project
If you require short-term support where the primary aim is to generate preliminary data, you should consider applying for our Therapeutic Discovery Pilot Award. If you require longer-term support where the aim is to answer an interrelated set of questions, you should consider applying for our Therapeutic Discovery Programme Award.
Applicants will have the opportunity to apply to the Antibody Alliance Laboratory (AAL) which collaborates with academics to support translation of novel biology into antibody therapeutics and diagnostics, as well as reagent tools to help build a target validation package. AAL provides access to AstraZeneca’s proprietary human antibody phage display library and established antibody-engineering technologies, alongside the extensive drug discovery expertise within the laboratory. When you first open up an application with us, we will discuss with you whether the AAL could support your proposal. If you wish to apply to the AAL to develop an antibody, you should include this in your application, including alternative plans should you not be successful and fill in the additional form.
You will be eligible to apply to use the Functional Genomics Centre (FGC). This is a joint initiative between CRUK and AstraZeneca and is a centre of expertise in genetics screens, cancer models, CRISPR vector design and computational approaches. If you are interested in accessing the FGC with your Pilot Award, you should approach the team directly to discuss whether they could support your proposal when you open an application with us. If you plan to apply to the FGC, you should include this in your application and request costs for access to the FGC. Additionally, your application will need to include alternative plans should you not be successful in your FGC application.
How to apply to this scheme
Overview of the application process
You must contact the research grants manager for an informal, confidential discussion about your proposed project. We will advise you on how to form suitable collaborations and ensure you are considering all necessary criteria within your proposal. Once the project is ready for a formal application we will open this on our electronic Grants Management System (eGMS).
Applications to our Therapeutic Discovery Project Awards are considered twice a year and follow a two-stage process:
1. A short outline application must be uploaded to eGMS. Outline applications will be considered by an Expert Review Panel (ERP)
2. Successful outline applicants will be invited to submit a full application to be submitted through eGMS. You'll be invited to an interview with an Expert Review Panel who will make funding recommendations to the Discovery Research Committee
All applications must be made through eGMS, where one PI must assume the responsibility of named Lead Applicant.
Outline application deadline - 4th August 2020
Full application deadline - December 2020 (TBC)
Interview date - March 2020 (TBC)
Committee review - May 2021
Before you begin your application
You must contact the research grants manager to discuss your proposal
Applications are assessed on their potential to deliver a novel preventative or therapeutic approach.
The Expert Review Panel will judge your proposal on:
- Scientific excellence: all applications must have a strong scientific rationale to support the proposed research proposal
- Cancer-relevance: likely to advance how cancer is understood, diagnosed or treated
- Collective track record: the team should demonstrate their combined strengths and potential to produce outstanding results
- The strength of your research team, research environment and collaborations in providing access to drug discovery expertise
- The translational work plan, which should include: Achievable milestones with go/no-go decision points; The specific deliverables of the project, for example assays, models or tools; A plan for further progression and the potential line of sight to the clinic at the end of the award
- Resources requested: the costs requested in an application should be for the direct costs of the research and be reasonably justified in line with the experimental plans, leveraging existing resources where appropriate
When you first contact us to discuss opening your application, we will discuss with you whether suitable collaborations are in place to support the project. We will be able to provide guidance on:
- Whether a Drug Discovery Unit may be able to assist your application
- Alignment of your project with the expertise of the individual unit
- Areas the unit will likely consider when assessing the feasibility of a collaboration
Working with a CRUK Drug Discovery Unit, or other professional drug discovery partner (academic or commercial) with experience of developing drug discovery proposals and project plans, will enhance your application for example by:
- Providing guidance on target validation necessary to engage a drug discovery partner to assist in the future development of your project
- Aiding you in defining specific milestones for the project, with associated go/ no-go decisions points
- Providing access to facilities and expertise (e.g. high-throughput screening or medicinal chemistry)
- Provide access to unique assays, models and chemical tools
- Participating in regular meetings to aid in project management and guiding the future direction of the project
- Our Drug Discovery Units seek to collaborate with the academic community as experts in specific areas of cancer biology. Potential applicants are not expected to have extensive experience of small molecule drug discovery. The aim is to build long lasting collaborations