Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.
A trial looking at mini stem cell transplants for myelodysplastic syndrome and acute myeloid leukaemia (FB - ATG)
We know that this is an especially worrying time for people with cancer and their family and friends. We have separate information about coronavirus and cancer. Please read that information alongside this page. We will update that information as guidance changes.
This trial was looking at reduced intensity stem cell transplants using thymoglobulin. It was for people who had poor risk myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML).
If you can't have full stem cell transplant, you may have a mini transplant. The chemotherapy is less intensive, so they are sometimes called reduced intensity transplants.
More about this trial
Doctors already used the drugs fludarabine, busulphan and alemtuzumab (MabCampath) for mini transplants. In this trial they were looking at a different combination of drugs – fludarabine, busulphan and thymoglobulin.
Thymoglobulin is a drug that suppresses the immune system. This means that it could help stop the new stem cells from attacking parts of your body, a possible complication called graft versus host disease (GVHD).
The aims of this trial were to see
- How well fludarabine, busulphan and thymoglobulin helped to stop
MDSand AML coming back after a mini transplant
- What the side effects were
Summary of results
This trial was never finished so there are no results available. The researchers were unable to collect data from enough patients.
How to join a clinical trial
Professor Ghulam J Mufti
Experimental Cancer Medicine Centre (ECMC)
Kings College Hospital NHS Foundation Trust