A trial looking at mini stem cell transplants for myelodysplastic syndrome and acute myeloid leukaemia (FB - ATG)

Cancer type:

Acute leukaemia

Acute myeloid leukaemia (AML)

Blood cancers

Leukaemia

Myelodysplastic syndrome (MDS)

Status:

Results

Phase:

Phase 2

This trial was looking at reduced intensity stem cell transplants using thymoglobulin. It was for people who had poor risk myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML).

If you can't have full stem cell transplant, you may have a mini transplant. The chemotherapy is less intensive, so they are sometimes called reduced intensity transplants.

More about this trial

Doctors already used the drugs fludarabine, busulphan and alemtuzumab (MabCampath) for mini transplants. In this trial they were looking at a different combination of drugs – fludarabine, busulphan and thymoglobulin.

Thymoglobulin is a drug that suppresses the immune system. This means that it could help stop the new stem cells from attacking parts of your body, a possible complication called graft versus host disease (GVHD).

The aims of this trial were to see