A trial of clofarabine and liposomal daunorubicin for children and teenagers with acute myeloid leukaemia (CLOUD)

You can enter this trial if you

• Have been diagnosed with AML that is not responding to induction chemotherapy and more than 20% of your bone marrow is made up of undeveloped blood cells (blasts) or
• Have AML that has come back within 1 year, or has come back more than once and more than 5% of your bone marrow is made up of blasts
• Are at least 6 months old, but have not yet reached your 18th birthday
• Are well enough to take part in the trial - this means you have a Karnofsky score of at least 50, or if your child is under 16, the trial team will use another scale to measure how much they can play and how much they need to rest
• Have satisfactory blood test results
• Have recovered from the side effects of any other treatment
• Are willing to use reliable contraception during the trial if there is any chance you could become pregnant

You cannot enter this trial if you

• Have AML that has come back more than a year after you were first diagnosed
• Have only one area of AML that is outside your bone marrow (isolated extramedullary leukaemia)
• Have AML that has spread to your brain or spinal cord (the central nervous system) and is causing symptoms
• Have had a stem cell transplant in the last 6 months
• Have any signs of a side effect called graft versus host disease after a transplant
• Have not recovered from other side effects of a transplant
• Have already had a large dose of daunorubicin or a similar drug (the trial doctors can advise you about this)
• Have had chemotherapy in the last 2 weeks
• Have had monoclonal antibody treatment in the last 2 weeks
• Are having any other treatment for AML, or any other experimental drug as part of another clinical trial
• Have certain heart problems (the trial doctors can advise you about this)
• Have an infection or any other serious medical condition