This trial is looking at a drug called MK-2870 for cancer of the digestive system

The following bullet points are a summary of the entry conditions for this trial. Talk to your doctor or the trial team if you are unsure about any of these. They will be able to advise you.

Who can take part

You may be able to join this trial if you have an adenocarcinoma  of one of the following cancers:

• bowel cancer that has spread to another part of the body (stage 4) or cannot be removed by surgery. Your doctor has tested the cancer cells and the results show that it is not MMRd  or MSI high . You have had treatment with 5FU and oxaliplatin. 
• pancreatic duct cancer that has spread to another part of the body or cannot be removed by surgery. You have had 1 course of treatment  that included the chemotherapy drug gemcitabine.
• bile duct cancer that has spread to another part of the body or cannot be removed by surgery. You have had 1 course of treatment that included the chemotherapy drug gemcitabine or 2 courses of treatment that included gemcitabine with a targeted drug  or an immunotherapy . 
• gallbladder cancer that has spread to another part of the body or cannot be removed by surgery. You have had 1 course of treatment that included the chemotherapy drug gemcitabine or 2 courses of treatment that included gemcitabine with a targeted drug or an immunotherapy. 

And all of the following apply. You:

• have an area of cancer that the doctor can measure
• have a sample of tissue (biopsy ) that the trial team can access and use
• have satisfactory blood test results
• are able to look after yourself but might not be able to do heavy physical work (performance status 0 or 1)
• are willing to use reliable contraception during treatment and for a period of time after treatment if there is any chance you or your partner could become pregnant
• are at least 18 years old

Who can’t take part

Cancer related
You cannot join this trial if any of these apply. You:

• have cancer where the bile duct and duct of the pancreas join and empty into the intestine (ampullary cancer) 
• have cancer spread to the brain, spinal cord or the tissue surrounding the brain. You can join if you had treatment for the cancer spread, if it is now stable and you have not had steroids for at least 2 weeks before starting the trial treatment.
• have ongoing side effects from previous treatment. This is apart from mild side effects and mild to moderate side effects that affect the nerves. 
• have had another cancer in the past 3 years that needed treatment or was getting worse. This is apart from successfully treated non melanoma skin cancer  and any carcinoma in situ  except for carcinoma in situ of the bladder. 
• have fluid around the abdomen (ascites), lung (pleural effusion) or heart (pericardial effusion) that needs treatment by draining or medication within 2 weeks of joining the trial
• have cancer treatment, including as part of another clinical trial, within 4 weeks of starting trial treatment
• have had treatment with another antibody drug conjugate  that works in a similar way to MK-2870. Your doctor will know about this. 

Medical conditions 
You cannot join this trial if any of these apply. You:

• have had eye problems such as severe dry eye syndrome, severe Meibomian gland disease or swollen, itchy eyelids. Or you have problems with the outer layer of your eye (cornea) healing. 
• have an active inflammatory bowel disease that needs treatment with medication, such as steroids , that damps down the immune system . Or you have a history of inflammatory bowel disease such as Crohn’s disease, ulcerative colitis or ongoing (chronic) diarrhoea. 
• had a heart attack, congestive heart disease, unstable chest pain (angina) or any other major heart problem  in the past 6 months
• have HIV that is not well controlled by medication. You cannot join the trial if you have, or have had, Kaposi’s sarcoma or Multicentric Castleman’s Disease due to your HIV.
• have active hepatitis B and active hepatitis C 
• have another active infection that needs treatment that reaches your whole body such as an antibiotic infusion or antibiotic tablets
• have taken medication that affects the CYP enzymes within 2 weeks of starting treatment. Your doctor will know about this. 
• have radiotherapy within 2 weeks of starting treatment. If you have radiotherapy to relieve symptoms (palliative radiotherapy) it is within a week of starting treatment.
• have ongoing side effects from radiotherapy 
• have an immune system  that is not working well. Or you are taking medication that damps down the immune system, apart from a small dose of steroids, within a week of starting treatment. 
• have had a stem cell or bone marrow transplant from a donor (allogeneic transplant )
• have had an organ transplant
• have not recovered from previous surgery or you have ongoing complications from surgery
• have any other medical condition, mental health condition or other circumstances that could affect you taking part in the trial

Other 
You cannot join this trial if any of these apply. You:

• are allergic or very sensitive to MK-2870, any of its ingredients or similar drugs
• have a live vaccine  within 30 days of starting trial treatment. You can have the seasonal flu and COVID-19 vaccines as they are not live vaccines. 
• are pregnant or breastfeeding