“I was keen to go on a clinical trial. I wanted to try new cancer treatments and hopefully help future generations.”
A trial looking at vitamin E and pentoxifylline for radiation fibrosis and lymphoedema after treatment for breast cancer
This trial looked at whether vitamin E and pentoxifylline helped to heal tissue damaged by radiotherapy for breast cancer. This trial was supported by Cancer Research UK.
Doctors often treat
Some research has suggested that it may be possible to treat radiation fibrosis, but results from other trials have been mixed. In this trial, the researchers wanted to find out if vitamin E (alpha-tocopherol) and a drug called pentoxifylline could help to heal tissue damaged by radiotherapy and so improve lymphoedema.
The aim of the trial was to see if having these 2 drugs helped to reduce lymphoedema after radiotherapy for breast cancer.
Summary of results
From their analysis of results, the research team say that vitamin E and pentoxifylline did not improve lymphoedema. They also found that the drugs made no difference to radiation fibrosis in the breast, chest or armpit.
The trial recruited 68 people who had at least a 20% increase in the size of one arm after having radiotherapy for breast cancer. The average length of time since having radiotherapy was 15 and a half years. Three quarters of the people taking part had surgery to remove lymph nodes from under their arm, as well as radiotherapy.
Half the people taking part took vitamin E and pentoxifylline tablets every day for 6 months. The other half took dummy tablets (
The research team measured their arm at the beginning of the trial and again after 12 months. They also examined and took photographs of any areas of tissue that had become hard due to radiation fibrosis in the breast, chest or armpit to see if these improved during the trial. They found very little improvement in either lymphoedema or radiation fibrosis in either group.
We have based this summary on information from the team who ran the trial. The information they sent us has been reviewed by independent specialists (
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor John Yarnold
Cancer Research UK
This is Cancer Research UK trial number CRUK/00/001.