A trial of temozolomide for children with neuroblastoma that has come back after treatment (NAG 2003 02)

This trial was looking at the chemotherapy drug temozolomide for children with neuroblastoma.

Neuroblastoma is a rare type of cancer that affects young children. Doctors usually treat it with chemotherapy, surgery and sometimes radiotherapy. But sometimes the treatment doesn’t work very well, or the cancer comes back after treatment (recurs). If this happens it is more difficult to treat.

Temozolomide is a chemotherapy drug that doctors use to treat some forms of brain tumour in adults (such as glioma). The researchers think temozolomide may be useful for treating children with neuroblastoma.

The aim of this trial was to see how well temozolomide worked for children with neuroblastoma that had not responded to treatment, or that had come back after treatment.