
Last year in the UK over 60,000 cancer patients enrolled on clinical trials aimed at improving cancer treatments and making them available to all.
This trial tried to find out if a dietary supplement could help abnormal cervical cells return to normal. This trial was supported by Cancer Research UK.
A cervical smear test can pick up different stages of ‘abnormal cells’ on the neck of the womb (the cervix). As these cells are ‘pre cancerous’, the treatment you have can prevent cervical cancer. What you have depends on whether the cells show borderline, mild, moderate or severe changes (dyskaryosis).
If you have moderate or severe cell changes, you will then have a colposcopy. This is a close examination of your cervix. If you have borderline changes, you will probably have another smear test 6 months later, or you may have a colposcopy. If you have mild changes you will either have another smear test 6 months later or a colposcopy.
A supplement called diindolylmethane (pronounced di-in-doll-ile-me-th-aine), called DIM for short, is found in vegetables such as broccoli, cabbage and cauliflower. Research has shown that DIM may change pre cancerous cells back to normal cells.
In this trial, women who had borderline or mild cervical cell changes took a form of DIM, called BioResponse DIM, every day for 6 months. The aim of this trial was to see if DIM helped abnormal cells return to normal.
The trial team found that taking diindolylmethane (DIM) for a short while was not likely to help abnormal cells of the cervix return to normal.
This was a randomised trial where neither the patient, nor their doctor, knew what they were taking (double blind). Of the 600 women who took part in this trial
After 6 months these women had a follow up colposcopy and cervical smear test
Of the 373 women who had DIM their colposcopy and cervical smear test
Of the 178 who had the dummy drug
As twice as many women took DIM, there was no difference statistically between the 2 groups. The trial team concluded that having DIM for 6 months was not likely to help abnormal cells of the cervix return to normal.
We have based this summary on information from the team who ran the trial. The information they sent us has been reviewed by independent specialists () and published in a medical journal. The figures we quote above were provided by the trial team. We have not analysed the data ourselves.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor Peter Sasieni
Professor Alison Fiander
Cancer Research UK
Cardiff University (School of Medicine)
Cervical Screening Wales (CSW)
NIHR Clinical Research Network: Cancer
Queen Mary University of London
This is Cancer Research UK trial number CRUK/04/027.
We have more information on the work of Professor Peter Sasieni.
If you have questions about the trial please contact our cancer information nurses
Freephone 0808 800 4040
Last year in the UK over 60,000 cancer patients enrolled on clinical trials aimed at improving cancer treatments and making them available to all.