A trial to see if there is a link between the enzyme thymidylate synthase and how people respond to treatment for non small cell lung cancer (The TS Study)

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Cancer type:

Lung cancer
Non small cell lung cancer

Status:

Results

Phase:

Phase 2

This study tried to find out if a substance produced in the body called thymidylate synthase affects how people respond to chemotherapy for non small cell lung cancer (NSCLC).

More about this trial

Doctors often use chemotherapy to treat  NSCLC. Pemetrexed and cisplatin are drugs that may be used.

Thymidylate synthase (TS) is a substance that the body produces naturally. Cancer cells need TS to be able to copy their DNA before they divide into 2 new cells.

Researchers think that treatment for NSCLC may work better in people who have low levels of TS in their body. But they don’t know this for sure yet. So in this trial, they measured the TS levels of everybody having treatment.

The aim of the trial was to see if there is a link between how much TS people produce and how well they respond to treatment with pemetrexed and cisplatin for non small cell lung cancer.

Summary of results

Despite attempting to contact the trial team, we have not been able to have the results for this trial checked.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Mayukh Das

Supported by

Eli Lilly and Company Limited
Experimental Cancer Medicine Centre (ECMC)

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Last review date

CRUK internal database number:

Oracle 4332

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Over 60,000 cancer patients enrolled on clinical trials in the UK last year.

Last reviewed:

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