
"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This trial is looking at a drug called nivolumab for people with diffuse large B cell lymphoma (DLBCL). It is for people whose lymphoma has come back or is no longer responding to treatment.
Diffuse large B cell lymphoma (DLBCL) is a type of non Hodgkin lymphoma. It is the most common type of high grade non Hodgkin lymphoma.
Doctors usually treat DLBCL with a combination of chemotherapy called CHOP and a drug called rituximab.This treatment is called R-CHOP. Some people with high grade non Hodgkin lymphoma may have and a stem cell transplant instead.
But sometimes DLBCL does not go away, or comes back after treatment. So doctors are looking for new treatments for people in this situation. In this trial researchers are looking at a drug called nivolumab.
Nivolumab is a type of drug called a monoclonal antibody. It may help the body’s immune system to attack lymphoma cells.
The aims of the trial are to find out
You may be able to join this trial if all of the following apply. You
You cannot join this trial if any of these apply. You
This is a phase 2 trial. The researchers need 120 people to join. Everybody taking part will have nivolumab.
You have nivolumab every 2 weeks through a drip into a vein. It takes an hour each time. You can continue to have treatment as long as it is helping you and the side effects aren’t too bad.
The trial team will ask you to fill out a questionnaire before you start treatment and at regular times during treatment. The questionnaire will ask about side effects and how you’ve been feeling. This is called a quality of life study.
For this trial, the researchers need a sample of bone marrow taken when you had a bone marrow test. If this isn’t available then you’ll need to have another biopsy taken. You must agree to this to take part in this trial.
You will see the doctor and have some tests before you start treatment. The tests include
Every 2 weeks you see the doctor for a checkup and some blood tests before having nivolumab. You have a CT or MRI scan every 2 months.
You see the trial doctor for a checkup, have blood tests and a CT or MRI scan
The most common side effects of nivolumab include
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor Peter Johnson
Bristol-Myers Squibb
Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
If you have questions about the trial please contact our cancer information nurses
Freephone 0808 800 4040
"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”