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A trial of nivolumab for advanced bowel cancer (ANICCA-CLASS II)

Overview

Cancer types:

Bowel (colorectal) cancer, Colon cancer, Rectal cancer, Secondary cancers

Status:

Results

Phase:

Phase 3

Details

This trial looked at how well nivolumab worked for bowel cancer that had grown into the tissue around the bowel or spread to another part of the body. This is called locally advanced or advanced bowel cancer.

It was for people with a certain type of bowel cancer called cancer.

People could join the trial between 2019 and 2021. The team first presented early results in September 2022. They published more results in a medical journal in December 2025.

Recruitment start: 28 August 2019

Recruitment end: 6 September 2021

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Professor Gary Middleton

Supported by

University of Birmingham

Bristol-Myers Squibb

Cancer Research UK

Experimental Cancer Medicine Centre (ECMC)

Last reviewed: 04 Feb 2026

CRUK internal database number: 16343

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